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The present 1nvestigation deals with the synthesis of some new salicylamidoacetyl sulfonamides 3a,b sallcylamldo ethylacetate 4, salicylamido acld hydvazide 5, which is conside red as the key intermediate for the synthesis several of new compounds such as salicylamido pyrzol 6 and pyrazolone 7. N-imido-derivatives 9, 10, 11, thiadiazsole 13, oxadiazole 14, 15, Schiffs bases 16a-f. Cyclocondensation of Schliffs bases with thioglycolic acid gave thiazolidinone 18a-c while with acetylchloride afforded azitidinones l9a-c and with acetic anhydride gave 1,4-benzoxazepine-3,5-dione. Some of the compounds were tested for their analgesic and antiinflammatory activities as well as ulcerogenic effects. Some derivatives were more effective than sallcylamlde and ulcerogenic activity was variably lowered.
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